Black Thyroid — Black thyroid syndrome is diffuse black discoloration of the thyroid noted during gross specimen examination associated with prior minocycline therapy.Q Clinical manifestations — Patients are typically asymptomatic with normal thyroid function. It is usually noted incidentally Minocycline and other tetracycline derivatives have been implicated as the causative agents, even after exposure as short as 12 days. Pathology — Gross examination shows a diffused black thyroid gland; in contrast, benign and malignant thyroid neoplasms are often hypopigmented .
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