Kidney transplantation is now a recognized method of treatment for patients with end-stage renal disease in current medical practice. There are numerous reports of beneficial effects of kidneys preservation in hypothermic machine perfusion on early and long-term graft survival. It allows assessment of the organ before transplantation through an analysis of perfusion parameters and biochemical tests. Published clinical studies have demonstrated that hypothermic machine perfusion reduces the number of delayed graft function (DGF) episodes and limits the occurrence of interstitial fibrosis/tubular atrophy and chronic rejection assessed by biopsy. This is of particular importance in the case of expanded criteria donors (ECD), where the risk of DGF is markedly higher.
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