Mucosa-Associated Lymphoid Tissue Lymphoma Endoscopy shows nodular erosions with necrotic material of the gastric body and fundus as well as larger irregular ulcers of the third portion of duodenus. It has long been known that the stomach is the most common location of lymphoma within the gastrointestinal tract. However, it is only in the past few decades that the reason for this fact has been found. The discovery of gastric Helicobacter pylori infection and its role in the pathogenesis of chronic gastritis, lymphoma and probably gastric carcinoma has revolutionized our definition of malignancy. The concept of a pathway of lymphoid hyperplasia (chronic gastritis) leading to lymphoid “dysplasia” (atypical lymphoid infiltrates) that further evolves into a proliferation that fulfils criteria for malignancy (lymphoma) has been compared to the adenoma-carcinoma sequence in epithelial neoplasia
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