MEDtube Science 2015 - Is Eating Seville Oranges Dangerous?

Grapefruits are commonly recognized as a cause of drugs interactions through affecting the cytrochrome P450 (CYPs). Large and diverse family of CYPs are protein enzymes with monooxygenase activity involved in both, the activation and detoxification metabolism of xenbiotics. Because of their function, they have been widely researched in vitro and in vivo. There are reports that different exotic fruits have effect on CYP proteins. The aim of this paper is to review recent research articles in order to identify fruits and their juices interfering with the metabolism of drugs and thus endangering the treatment of chronic diseases. Material and Methods. A systematic review of the literature from PubMed resource with access to MEDLINE was performed. Summaries were obtained from 15 articles published between 1997 and 2014 and closely related to the given keywords. Of these 15 articles, 4 (published between 2002-2012) were fulfilling the pre-determined criteria and were assessed in details. Results and conclusion. Seville oranges and their juice can endanger the treatment of chronic diseases through inhibition of cytochrome P450 and drug interactions. The diet of transplanted organ recipients should be controlled and they should avoid not only grapefruit, but also Seville orange consumption.