Ampullary cancer accounts for approximately 0.2% of all gastrointestinal tract malignancies. The Courvoisier sign, painless jaundice associated with a palpable gallbladder, may be present. Unlike that due to a neoplasm, obstructive jaundice due to a stone causes scarring of the gallbladder, precluding its distension. Although biopsy is not 100% accurate.
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