This image and the video clips shows the diameter of the tumor. The discovery in 2000 of the efficacy of imatinib, an inhibitor of the BCR-ABL oncoprotein used in the treatment of chronic myeloid leukemia (CML), in treating metastatic gastrointestinal stromal tumor has revolutionized the care of patients with GISTs. Prior to the advent of immunohistochemical methods enabling the specific identification of c-KIT positive tumors, these tumors were inaccurately classified as gastric or intestinal smooth muscle tumors (leiomyomas or leiomyosarcomas)
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