Embryology of the Pancreas

Summary of the video for your notes: 1. Pancreas is formed by two buds, the dorsal and ventral buds. They develop from the lining of duodenum. 2. When the duodenum rotates to the right side, the ventral bud moves dorsally shifting itself to the final position of inferior and posterior to the dorsal bud. 3. The parenchyma and duct systems then fuse. 4. The ventral bud forms the uncinate process and the inferior part of the head of the pancreas. 5. The remaining part of the pancreas is derived from the dorsal bud. 6. In 10% of cases, the duct systems fail to fuse and the original double system persists. 7. (Not in video) In the third month of fetal life, pancreatic islets of Langerhans develop from the parenchymatous pancreatic tissue and scatter throughout the pancreas. Insulin secretion begins about the fifth month. Glucagon and somatostatin secreting cells also develop from the parenchymal cells.