Azathioprine - Pharmacology, Mechanism of Action, Side Effects
3 years ago
An alternative metabolic pathway of 6-Mercaptopurine is via xanthine oxidase which will form 6 thiouric acid which is non toxic and can be cleared by the body. Another alternate metabolic pathway of mercaptopurine is via thiopurine methyltransferase forming 6methyl mercaptopurine which is also non toxic and can be cleared by the body. Myelosuppression is the primary side effect and can lead to malignancy especially skin cancer and lymphoma.
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