Histopathology Blood -Acute Leukemia

In this video you can see a comparison of normal and pathological blood smears. In sick blood smear there is a higher ratio of nucleated cells (white cells) and non-nucleated cells (red cells). There is also only few platelets. Proliferating cells have at least one nucleolus, they are big and have no differentiation in cytoplasm - they are blast cells, which should be absent in healthy blood. In the gross picture you can see that hematopoietic marrow is in the whole bone (in this case it's producing mostly blasts) and in healthy adult person bone marrow is filled with fat.
Video by WashingtonDeceit