MEDtube Science 2014 - Histological lesions in expanded criteria renal allografts

Backgrounds: The shortage of organs for transplantation has forced the transplant community to create another donors subgroup – expanded criteria donors (ECD). The aim of this study was to establish the relationship between expanded criteria donors parameters and chronic histopathological lesions and then histopathological lesions in relation to transplant kidney graft function and survival.
Material and methods: One hundred and seventy two patients received renal transplants from deceased donors. The data on donors and recipients were collected. The patient and graft survival rates were noted. The delayed, slow graft function and creatinine concentration were analysed. The chronic lesions in kidney biopsies were evaluated according to Banff criteria (2007).
Results: Kidneys procured from ECD (n=43) display chronic histological lesions like interstitial fibrosis (IF), tubular atrophy (TA), arteriosclerosis(AS), arteriolar hyalinization (AH) and glomerulosclerosis (GS) significantly more frequently than standard criteria donor kidneys (n=128).
TA was associated with higher creatinine concentration. Popular histological score systems (BANFF, Pirani, CADI) did not have correlate with kidney graft survival and function.
Conclusions: ECD kidneys are more likely to contain chronic histological lesions on biopsy. There is a correlation between chronic histological lesions and kidney graft function.