Type III hypersensitivity also known as immune complex hypersensitivity reaction. Is a reaction where formation of the antigen-antibody complexes deposit in tissues activating complement proteins and so the inflammatory response in tissues. The antigen antibody complex are the immune complexes and these will circulate around the body. The immune complexes can be cleared by macrophages in the spleen or liver, but when not cleared immune complexes will deposit into various tissues, where they induce complement activation. Complement proteins are circulating protein which when active trigger a cascade of activating other complement proteins promoting the immune response and inflammation.
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