Ex-Vivo Lung Perfusion with Usage of 10 Degrees Centigrade Instead of Classic One

A recent advancement in ex vivo lung perfusion and preservation (EVLPD) involves the implementation of ultracold perfusion at 10°C, which represents a significant evolution from traditional static cold storage at 4°C and normothermic EVLP systems operating at 37°C. This intermediate hypothermic approach offers a balance between metabolic suppression and cellular function preservation, minimizing ischemia-reperfusion injury while extending safe preservation times. Compared to conventional cold storage, 10°C perfusion better maintains endothelial integrity and reduces inflammation. Unlike routine normothermic EVLP, which allows assessment and reconditioning but has time limitations and higher metabolic demands, the 10°C system allows extended lung preservation—up to 24 hours or more—without compromising graft viability. Early clinical and preclinical studies show promising outcomes in transplantation success and graft function, positioning 10°C EVLPD as a potential game-changer in organ utilization and logistics for lung transplantation.