Cyclophosphamide - Pharmacology, Mechanism of Action, Adverse Effects

Cyclophosphamide is a powerful immunosuppressant with a rapid onset of action (days to weeks). Cyclophosphamide is a popular chemotherapy agents used to treat lymphoma, multiple myeloma and leukaemia. In rheumatology it has a role in the treatment of vasculitis, life threatening complication of systemic lupus erythematosus and interstitial lung disease. Cyclophosphamide is an alkylating agent and works by disrupting the cell cycle targeting rapidly dividing cells such as cancer cells and immune cells because it is an immunosuppressant.

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