Cholangiocarcinoma that infiltrated a Periampullary Duodenal Diverticula and the head of the pancreas (6 of 20)

Clinical Features


Most common presenting clinical features of perihilar or extrahepatic tumours are those of biliary obstruction: jaundice, pale stool, dark urine, and pruritus.
Right upper quadrant pain, fever, and rigors suggest
cholangitis (this is unusual without drainage attempts)
Cholangiocarcinoma usually presents after the disease is advanced. This is particularly true with more proximal intrahepatic and perihilar tumours obstructing one duct, which often present with systemic manifestations of malignancy, such as malaise, fatigue, and weight loss.
Some cases are detected incidentally as a result of deranged liver function tests, or ultrasound scans performed for other indications.