Inhibitors of epidermal growth factor receptor – a new hope for patients with neuropathic pain?

Arm ache. Close up of businessman hand tired from typingNeuropathic pain, which concerns more and more patients, is currently a huge therapeutic challenge. Mechanism of its emergence is not exactly known yet and effectiveness of treatment with the use of standard pharamacotherapy involving analgesics, anticonvulsive drugs and antidepressants is usually not satisfactory. That is why scientists look for alternative treatment methods. One of the aim of new therapies may be epidermal growth factor receptor (EGFR). Read full text »

Scientists discovered odor receptors in lungs – what is their clinical significance?

medical doctor looking at x-ray picture of lungs in hospitalResearchers from Washington University in St. Louis and the University of Iowa announced that odor receptors are presented not only in the nasal cavity but also on the surface of specific lung cells. Their data has been recently published in the Journal of Respiratory Cell and Molecular Biology. Read full text »

PD-1 inhibitors in cancer therapy

PD-1 is a receptor which, through a variety of metabolic processes, leads to inactivation of T cells. In the therapy of the cancer, one of the promising new drugs is BMS-936 558, an antibody directed against PD-1 receptor. The effectiveness of the new therapy has been demonstrated in large randomized trials for renal cancer, non-small cell lung cancer and melanoma. Currently, the drug is in the second phase of clinical trials (treatment of renal cell carcinoma). The obtained results are very promising, however the effect of the antibody must be evaluated in the further studies.

Read full text »

Enzyme PTPN23 is important regulator of aggressive breast cancer development

Scientists from Cold Spring Harbor Laboratory (CSHL) have identified an enzyme, which is significant regulator of breast cancer development and metastasis. PTPN23 is intracellular protein, which plays key role in cell signaling and can promote metastases. Read full text »

New drugs to combat migraine

Migraine is a problem that affects approximately 15% of adults. A splitting headache is often accompanied by a number of neurological and non-neurological manifestations. Patients affected by this ailment are put under a higher risk of developing such conditions as anxiety or depression. Migraine has an influence on the visuo-spatial memory and seriously affects selective attention tasks. This malady disables the proper function of the human body – it brings a headache of such a severe intensity that it may be aggravated by just a normal physical activity. Therefore migraine is a major problem for a working community. Read full text »