New treatment perspectives of osteoporosis

iStock_000015704019XSmallOsteoporosis is a generalized metabolic bone disease, characterized by low bone mass, impaired microarchitecture of the bone tissue and consequently the increased susceptibility to fracture. It occurs most frequently in women after menopause (postmenopausal osteoporosis). The bones undergo remodeling throughout life. Two processes are responsible for their density – bone resorption stimulated by osteoclasts and bone formation performed by osteoblasts. This fact made these cells the main goal of pharmacotherapy for osteoporosis. Read full text »

Dental implants for people with significant bone loss and osteoporosis

Dental implant treatment is becoming more popular around the world, often replacing traditional prosthetic treatment. Dental implant market is growing rapidly. Unfortunately, for some patients this treatment is not available due to systemic and local contraindications. With the discovery of the Universitat Jaume I scientists in Castellón comes a great oportunity for a group of patients who have been refused a dental implant treatment before.

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Obesity, diabetes, depression and osteoporosis – current nightmares of humanity

Obesity is linked with excessive accumulation of fat tissue and with adverse effects on health. Type 2 diabetes has become one of the main lifestyle diseases and is one of the most common problems in everyday medical practice. Worldwide, in every 10 seconds it is diagnosed in two individuals and one person dies because of its complications. Depression is linked with chronic and sustained despondence, low self-esteem and loss of ability to feel pleasure. Osteoporosis is a chronic metabolic disease, which is characterized with decrease of bone mass and changes in the bone microarchitecture, leading to increased risk of fractures.

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Dried plum for bone loss

Conventional approach to the therapy of osteoporosis has its drawbacks, hence various alternative substances are tested for their beneficial effects on bone metabolism. As soya isoflavons seem to lose their strong position in prevention of osteoporosis (1), the search for other plant-derived agents continues. Researchers from the Florida State University have been examining the healing potential of prunes for many years. They have just published their latest study (2), which suggests that enriching a diet with dried plums results in the increase of bone mineral density (BMD). Read full text »

FRAX® algorithm – a new method of osteoporosis detection?

Recently people suspecting to have osteoporosis have a new simple method of diagnostics. A special tool allowing for detection of the disease is FRAX® algorithm which was developed by the World Health Organisation in collaboration with the Centre of Bone Metabolic Diseases, University of Sheffield (Great Britain). The algorithm is generally available on the Internet. An article which presents this tool also provides with broader introduction to its properties and directions for its use. Read full text »

The role of VDR and ER- α genes in the pathogenesis of osteoporosis.

Osteoporosis is a chronic metabolic disease, leading to increased risk of fractures. The essence of its pathogenesis is a disorder in transformation of the bone tissue, associated with osteoclasts and osteoblasts, which is a constant creation of new bone with tissue resorption at the same time. The balance of this process depends on many factors, eg. hormonal, inflammatory, environmental and genetic. Articles, which lay down the role of genetic factors affecting the occurrence of osteoporosis, appeared mostly at the beginning of the 21st century [1]. 
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