A diet rich in broccoli can reduce the risk of liver diseases

iStock_000034378286_FullThe results of the study published in Journal of Nutrition indicate that eating plants such as broccoli, cabbage and Brussels sprouts can reduce the risk of liver diseases, especially cancer.

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Alfa-L-fucosidase as a new potential marker of non-alcoholic fatty liver disease

Team of doctors.Non-alcoholic fatty liver disease (NAFLD) is currently the most frequent chronic liver disease. Although first mentions of the disease go back to the second half of 20th century, the scientists still find new missing links in pathogenesis chain of NAFLD. A group of researchers from First Affiliated Hospital of Zhejiang University of Medicine in China have shown a positive correlation between level of alpha-L-fucosidase in blood plasma and the risk of non-alcoholic fatty liver disease development [1]. Read full text »

Can air pollution contribute to serious liver diseases?

Team of doctors.Scientists from Wayne State University School of Medicine’s Centre for Molecular Medicine and Genetics have proven on a mice model that inhalation of particles of pollution that are smaller than 2.5 (PM 2.5) might lead to an exacerbated production of fibrous tissue in liver and, in turn, cause liver cirrhosis. Read full text »

The next step in the fight against paracetamol overdose

The liver, which is a part of the gastrointestinal tract is the largest organ of the human body. Its function does not end at helping the digestion of food. It plays a key role in the homeostasis of the body. It participates in the metabolism of carbohydrates, fats and proteins, and also the synthetic processes take place in it, such as the coagulation factors. It is involved in the detoxification of chemicals, drugs and other xenobiotics, too. Due to variety of its functions is still exposed to damage. Although this organ has a large regenerative abilities, the possibilities of compensation in the course of acute liver failure are limited. Read full text »

Importance of newfound mutation of HBV virus: W4P/R

Korean Scientists, Lee et al., in their epidemiological molecular investigation identified specific W4P/R preS1 mutation of hepatitis B virus (HBV) in male patients with genotype C of chronic infection. They indicate that it may contribute to hepatitis progression and the development of hepatocellular carcinoma (HCC). Read full text »

HCV vaccine – it’s coming in big steps

In the UK alone, 500 000 people are infected with Hepatitis C virus (HCV) and still, most of the patients are not diagnosed. Therefore, HCV infection is a major cause of liver transplantation there. A few years ago, scientists have found monoclonal antibodies which gave hope for the acquisition of an effective vaccine. Now, the first results of the testing of vaccines based on adenoviral vectors have occurred. Read full text »

Drugs and it’s metabolism – supercomputer simulations – ability to understand it

Scientific research on supercomputer simulations of cytochrome P450 has been published in the Biophysical Journal. The article describes a virtual presentation of the actual activity of the enzyme. Simulation was performed to better understand the detoxifying role of the cytochrome P450 and facilitate further studies. Read full text »

Family physicians in battle with alcohol

The European Union through the 7th Framework Programme is funding the project ODHIN designed to increase the activity of the family physicians in the delivery of health care interventions for the hazardous and harmful alcohol drinking patients. The project began in January 2011, it will end in December 2014. Nineteen partners from 9 European countries are taking part in the project. Poland is represented by 3 institutions. Read full text »

Miniature human liver the latest achievement of tissue engineering

During the last year’s meeting of The American Association for the Study of Liver Diseases(1) (AASLD) the innovative technique of bioscaffolding has been presented. On the basis of this novelty scientists managed to produce a fully functional liver ­ a hybrid of animal and human cells. This is the next important step in regenerative medicine. Read full text »