LOX inhibitors – New therapeutic aim to fight breast cancer metastases into bones

iStock_000019976173_DoubleDiscovery of scientists from University of Sheffield’s Department of Human Metabolism and University of Copenhagen opens a new therapeutic window in case of patients with invasive form of breast cancer. They showed that Lysyl oxidase homolog 2 (LOXL 2) significantly contributes to development of breast cancer metastases into bones and probably into lungs. Read full text »

Beclin-1 as a new aim of breast cancer therapy?

The latest research show connection between autophagy disorders and prevalence of malign subtype of breast cancer. A group of scientists from the United States have discovered correlation between decrease of beclin gene expression (BECN1) and triple negative breast cancer. Results of analyses conducted at university in Texas were published in EBioMedicine magazine. Read full text »

A new breast cancer biomarker discovered?

iStock_000015704019XSmallBreast cancer is the most common malignant tumour in women. It is estimated that it leads to over 500 000 deaths annually. The survival rate varies from 80% in Northern American countries and Sweden, to 60% in moderately developed countries to only 40% in the poorly developed countries. The most important factors influencing prognosis in the patients are still both the stage of development and the timing of diagnosis of the tumour. That is why the scientists are trying to find other, new biomarkers of breast cancer that would allow making an early diagnosis and thus, launching the treatment accordingly soon. Read full text »

Role of microbiome in the development of women breast cancer

Microbiome of breast tissue appears to be essential for health and disease. Recent studies performed by US scientists indicate that the formation of breast cancer in women may be related to the changes in the quality/quantity in the microbiome of breast tissue. The results of this study was published in the PLOS ONE. Read full text »

Tomosynthesis supporting mammography in screening studies

Mammography is recently gaining important extension, increasing sensitivity and specificity of imaging early stages of breast cancer. The tomosynthesis technique combined with classic mammography can provide earlier and more accurate identification of breast lesions. Read full text »

Research on breast tissue microbiome

Are bacteria and their metabolites present in human breast tissue? What is their significance in health and disease? Recent studies of Urbaniak et al. have shown the presence of microorganisms in breast tissue. The researchers suggest that depending on composition of those microbiome the immune system cells and carcinogenesis may be differently stimulated. Read full text »

cMethDNA assay versus traditional imaging tests in monitoring response to chemotherapy and recurrence of breast cancer

Researchers from Johns Hopkins Kimmel Cancer Center in Baltimore have designed a new diagnostic test that will help to improve monitoring of the patients with breast cancer after antineoplastic treatment. The latest reports on the cMethDNA assay, which can detect changes in DNA methylation in 10 breast cancer-specific genes, were published in ‘Cancer Research’. Read full text »

Lung cancer – does high soy intake increase the chance of survival?

Lung cancer is the most common malignant neoplasm in the world and the most frequent cause of cancer deaths among men and second after breast cancer among women. Tobacco smoking is the most important risk factor of cancer development. Asbestos, radon gas, genetic factors, air pollution and passive smoking also play a significant role. Adenocarcinoma, localized in peripheral parts of lungs, is the most often diagnosed cancer among women and non-smokers. Read full text »

The results of genetic mapping in breast cancer

Breast cancer is one of the most common cancers in women. Since the 70th, until the 90th twentieth century, a steady increase in the incidence of breast cancer could be observed. A breast cancer is now the cause of more than 450 000 deaths per year. Researchers from The Cancer Genome Atlas mapped genetically over 800 samples from different patients with breast cancer. The results were published in the Nature, 23 September 2012. The study takes into account the type and number of mutations, miRNA correlation with mutations, DNA methylation, and the number and type of amplified genes. Integrated molecular analysis of breast cancer broadens our knowledge of the disease and points to genetic factors affecting the formation and progression of cancer. Read full text »

A vaccine for breast cancer

A new vaccine (Neuvax, nelipepimut-S or E75), which can prevent recurrence of early-stage, HER2 medium or low expression breast cancer, is being tested. Currently, since 2011 the vaccine is in a third phase of clinical trials but the preliminary results will be known in 2015. Vaccine is directed against E75 peptide isolated from the protein receptor HER2/neu. The results of the first and second phase of trials indicate reduced recurrence of the cancer than in the control group, lower mortality rate and the absence of bone metastasis in case of recurrence. In the article the way of action, patients’ criteria selection, results of the first and second phase of clinical trials, toxicity as well as perspective of spreading the vaccine, will be presented. Read full text »