Blood-brain barrier (BBB) has always posed a challenge for pharmacology. So far, there is no completely effective method to administrate peptide drugs, antibiotics and chemotherapeutic agents through the BBB (intrathecal injections are the alternative). The development of an effective penetration method through the blood-brain barrier would open new possibilities in the treatment of central nervous system (CNS) diseases with peptide drugs. Anand P et al. hit upon an innovative idea to overcome this problem. They used specially modified bacteriophages as nanocontainers full of painkillers, which allowed the application of the substance in the target area of action.
Bronchial asthma in children is one of the most common respiratory tract diseases. It comes in different, often simultaneously occurring, clinical manifestations. The code of conduct in case of asthma is very effective and, in most cases, it allows for a comprehensive control of the disease. However, despite of that, during the last 20 years an increase in both incidence and hospitalisation rate has been noted due to asthma. A team of scientists from University of British Columbia (UBC) and Children’s Hospital in Canada has found the possible cause of this state of matters while investigating the problem. Read full text »
Scientists from Friedrich-Alexander-University Erlangen-Nuremberg and Ruhr University Bochum in Germany conducted a research which showed that intestinal flora, as well as the type of fatty acids in the daily diet, through the influence on the cells of the immune system have an impact on exacerbation of multiple sclerosis. The results of the study were published in “Immunity” magazine. Read full text »
Scientists from Stanford University School of Medicine have made an attempt to describe the differences in both composition and amount of bacteria in the birth canal of women who gave birth prematurely and at a due date. Their research has led to discoveries that might soon contribute to designing new screening that would allow for assessing the risk of premature labour in very early stages of pregnancy.
Physiological flora of the organism are microbials present in the human body from birth to death. According to various estimates adult human has about 1014 microorganisms adapted to conditions in which they exist. Microbials are found on the skin, digestive tract and vagina. A team of scientists from Bailor College of Medicine in Houston discovered that microorganisms are also present in the placenta and may influence the course of pregnancy. Research was published in Sience Translational Medicine magazine. Read full text »
Researchers in Germany have developed sugar-free candy containing dead bacteria designed to compete with oral cariogenic pathogens. The results of the study are extremely promising. Read full text »
Scientists from Singapore Immunology Network (SigN) in cooperation with Newcastle University have discovered a new class of white blood cells which activate the response of immunological system to alien antigens. It has a chance to be a breakthrough in creation of vaccines against many dangerous diseases such as hospital acquired pneumonia, hepatitis B or tumours.
Colonorectal cancer is a major health problem across the globe. Its occurrence is highest in the developed countries in North America and Europe. It is considered as the second most common cause of death from neoplasma. Only in 2008 1.23 million new cases were reported and 608 000 deaths due to the disease. At the end of August a new study suggesting an association Fusobacterium of the oral cavity and the occurence of colorectal cancer was published. Intestinal bacteria inhabiting in the oral cavity may have an impact on the immune response and activation of supresor genes. The research team hopes to further research in order to establish quicker and simpler methods of diagnosis, prevention and treatment of colorectal cancer. Read full text »
Periodontitis is the second most common disease of the oral cavity worldwide. In the United States it affects 30-50% of the population, while in Germany about 12 million people suffer from periodontitis. Apart from the obvious problems arising from the loss of connective tissue attachment and alveolar bone structure, periodontal inflammation can lead to a general infection of the body. Fraunhofer Institute of Cell Therapy and Immunology has designed artificial discs detecting 11 main bacteria that can lead to periodontal disease. Read full text »
Jorge A. Guzman, MD, has indicated to Physician’s Weekly that he has received grants/research aid from bioMerieux, speakers fees for bioMeriuex, and consulting fees for Pfizer.
Written for Physician’s Weekly.
Sepsis is a potentially fatal condition that strikes an estimated 750,000 people each year in the United States. Defined as the body’s reaction to infection (whether bacterial, viral, fungal, or parasitic), sepsis is the most common underlying cause of mortality in non-coronary ICUs. It can rapidly lead to systemic inflammatory reactions and, eventually, organ dysfunction or failure. People who are at greatest risk of developing sepsis include patients who are very young or very old, those with compromised immune systems, those who are hospitalized and are very sick, and individuals with invasive devices (eg, urinary catheters or breathing tubes).