The number of people with diagnosed overweight or obesity is rapidly growing worldwide. The problem concerns both, children and adults. According to World Health Organization, there is 1,6 bn overweight and 522 m obese people around the world. The latest research conducted in the United States showed that high-fat diet impairs cognitive processes of human organism such as memory or learning.
As the years go by, more and more people are struggling with allergic rhinitis. Permanent rhinorrhoea, sneezing or nasal congestion caused by inflammation of nasal mucosa are the reasons of common use of variety of pharmacological substances which are available in the drug stores. None of the groups of medicines which are currently used during treatment of rhinitis – steroids, antihistamines, antileukotrienes, immunotherapy etc., doesn’t cure it completely, so search for something more effective is still in process. Read full text »
It has been observed that the incidence of childhood asthma is gradually increasing in developed countries. It is estimated that one-third of the young population will suffer from this disease in the near future. Diagnosing asthma in children is difficult. It consists mainly of checking clinical symptoms: cough, dyspnoea and wheezing. Asthma attack can be provoked by infection of upper respiratory tract, contact with allergens, tobacco smoke, certain medications and physical activity.
Proton pump inhibitors (PPIs) are currently one of the most effective and most widely used drugs in the prevention and treatment of disorders associated with excessive secretion of hydrochloric acid. Recent reports suggest that polytherapy with PPI, clopidogrel and acetylsalicylic acid in patients after percutaneous coronary intervention is associated with the possibility of adverse interactions in the form of, inter alia, acute coronary syndromes, stroke, and even death. The latest research clearly indicate that simultaneous use of proton pump inhibitors together with dual antiplatelet therapy does not increase the risk of adverse cardiovascular events.
Cancer chemoprevention involves the chronic administration of natural or synthetic substances to reduce or delay the incidence of malignancy. Research team from University of Pittsburgh School of Medicine and University of Pittsburgh Cancer Institute investigated the potential chemopreventive activity of sulforaphane, compound obtained from broccoli, against carcinogen-induced oral cancer. The study was recently published in the journal Cancer Prevention Research.< Read full text »
Depression is one of the main problems of public health worldwide. Till now, its etiology is not fully understood. From the psychiatric point of view depression is referred to as syndromes of depressive symptoms occurring in the course of affective disorders. These are manifested mainly by depressed mood (sadness, grief, low self-esteem, pessimism and suicidal thoughts), anhedonia, reduction of psychomotor motivation, circadian rhythm disorder. Over the years, the influence of various factors on the incidence of depression was studied. Nevertheless, scientists devoted little attention to assess the impact of diet or supplementation of specific macro and microelements. The recounted article focuses on assessing the effect of magnesium on the incidence of depression.
Neuropathic pain, which concerns more and more patients, is currently a huge therapeutic challenge. Mechanism of its emergence is not exactly known yet and effectiveness of treatment with the use of standard pharamacotherapy involving analgesics, anticonvulsive drugs and antidepressants is usually not satisfactory. That is why scientists look for alternative treatment methods. One of the aim of new therapies may be epidermal growth factor receptor (EGFR). Read full text »
Potential health benefits offered by the introduction of dark chocolate to your daily diet are still growing. The ingredients in cocoa not only improve our mood but also prevent obesity and reduce blood sugar levels which leads to preventing type 2 diabetes. It was also proved that eating chocolate lowers blood pressure. This time, researchers examined the effects of daily consumption of chocolate during pregnancy on fetal growth and development. The results were presented at the congress of The Society for Maternal-Fetal Medicine in Atlanta in 2016. Read full text »
Blood-brain barrier (BBB) has always posed a challenge for pharmacology. So far, there is no completely effective method to administrate peptide drugs, antibiotics and chemotherapeutic agents through the BBB (intrathecal injections are the alternative). The development of an effective penetration method through the blood-brain barrier would open new possibilities in the treatment of central nervous system (CNS) diseases with peptide drugs. Anand P et al. hit upon an innovative idea to overcome this problem. They used specially modified bacteriophages as nanocontainers full of painkillers, which allowed the application of the substance in the target area of action.