Male Infertility – Causes, Diagnosis and Management. A Review

Abstract: The World Health Organization defines infertility as an inability to get pregnant after a year of regular intercourse, 3-4 times a week, without use of preventive methods. The problem of infertility concerns about 15% of the population, in 20-30% of cases the cause is on the male side, in 20-35% couples struggle with female infertility, and in 25-40% of cases fertility problems concern both partners. Male infertility is defined as the inability of a man to cause pregnancy in a fertile woman. Male infertility is caused by change in sperm concentration and/or motility and/or morphology in at least one sample of two semen analyses. Read full text »

The Correlation Between Living Donor’s Glomerular Filtration Rate and Early Kidney Allograft Function

Abstract: Glomerular filtration rate of living kidney donor candidate must be appropriate to provide him sufficient filtration after unilateral nephrectomy and to ensure satisfactory renal graft function to recipient as well. Predictors for immediate function of living donor kidney transplant have not been well defined yet in the literature. Meanwhile, immediate graft function is well-known as closely related with better long-term outcome of transplantation procedure. The aim of the study was to analyse the impact of donor’s pre-donation estimated glomerular filtration rate on initial function of living donor kidney allograft. Analysed set consisted of 129 living kidney donors. Read full text »

Predictive Factors of Immediate Graft Function for Living-donor Kidney Transplant

Abstract: Favorable outcome of kidney transplantation is particularly expected in the case of living donation. Satisfactory result can be referred as immediate graft function, defined by fast postoperative recovery of renal function with satisfactory diuresis and no further need for dialysis. Prospective analysis of 40 living-donor renal transplants was performed to assess whether there are any predictive factor of immediate graft function. Patients were compared in two groups in accordance with their initial graft function (immediate vs. slow or delayed). Read full text »

Non-melanoma Skin Cancers: Perspectives of Early Diagnosis and Therapy

Abstract: Non-melanoma skin cancers (NMSC) belong to the group of most frequent malignant cancers among Caucasian race. Similar to other cancer types, NMSC progression is an outcome of environmental factors and genetic background. The predominating risk factor for NMSC is the prolonged exposure to ultraviolet (UV) light. The origin place for non-melanoma skin cancers is the epidermis. There are two main types: basal cell carcinoma (BSC) and squamous cell carcinoma (SCC). Basal cell carcinoma origins from the basal layer of epidermis. Read full text »

How Much Do We Know About Healthy Tanning Without Melanoma? A Questionnaire Study

Abstract: Melanoma develops rapidly from epidermal skin cells known as melanocytes, proceeding in a short time to the advanced stage of disease. Furthermore, it reveals an alarming increase in annual incidence. The essential solution is focused on appropriate prevention and lifestyle. The aim of the following study is the assessment of the prophylaxis use during exposure to detrimental ultraviolet radiation. The research enrolled 208 randomly selected respondents in an online survey, who answered 25 single and multiple-choice questions about melanoma prevention. Read full text »

Inhibitors of Perk-dependent Signaling Pathway as a Promising Therapy for Cancer Treatment

Abstract: Currently, cancer constitutes a primary health problem worldwide, since elimination of cancer cells is still inadequate due to insufficient treatment strategy. The newest data has reported that PERK-dependent signaling branches have a significant impact on development and progression of many human diseases including cancer. Hypoxia is the major hallmark of tumour microenvironment, that is strictly associated with rapid cancer progression and induction of metastasis. Low oxygen tension within cancer cells may trigger aggregation of unfolded and misfolded protein within the Endoplasmic Reticulum (ER) lumen and subsequently evoke ER stress condition. Read full text »

Elicitation and Elicitation Supported With the Phenylpropanoids Pathway Feeding for the Elevation of Phenolics Content in Quinoa Sprouts

Abstract: The aim of this study was to evaluate the combined action of phenylpropanoids feeding (shikimic acid, phenylalanine, tyrosine) and elicitation as a strategy for the elevation of phenolic content in quinoa sprouts. The highest increase of flavonoids content was found for the sprouts treated with shikimic acid. All the studied modifications increased the antioxidant potential of sprouts. Read full text »

The Lower Urinary Tract Dysfunction as a Challenge in Renal Transplantation

After the implementation of complex urological reconstructive procedures, kidney transplantation in patients with no functioning urinary bladder has become possible. However, patients with anatomical and/or functional dysfunction of the lower urinary tract (LUT) are a challenge for the renal transplant surgeons. In patients with LUT, the native bladder may be suitable for transplantation, otherwise intestinal reconstruction or diversion may be required. Read full text »

Fetal Skull Defects – the Best Method of Delivery

Neural tube defects (NTDs) are birth defects of the central nervous system that originate during embryonic development when the neural tube fails to close completely. They are the second most frequent category of congenital anomalies, after congenital heart disease. They happen in the first month of pregnancy, often before a woman even knows that she is pregnant. Recent developments in medicine have improved prenatal diagnosis, so that NTDs are diagnosed earlier and the diagnosis is more certain. Read full text »

Preoperative Immunonutrition in Gastrointestinal Cancer Patients

Surgical procedures due to gastrointestinal tumors are associated with increased risk of postoperative complications and mortality. This is a result of malnutrition and impairment of the immune system. Using nutritional treatment containing immunomodulatory components before surgery may improve the nutritional status of patients and also the immune system by stimulating the host`s immune response, improving the nitrogen balance and controlling the inflammatory response. The nutrients with immunomodulatory effect include: arginine, glutamine, -3 fatty acids, and nucleotides. Read full text »