Impacted uterine myoma in a 14 week pregnant patient

Uterine myomas are some of the most frequent neoplasms in women in the reproductive age. The frequency of uterine myomas in pregnancy varies between 0.1 and 3.9 %. The pregnancy in a woman with uterine myomas is usually uncomplicated, but in 10% of them, the myomas may cause symptoms. The study presents the case of a pedunculated submucosal myoma impacted in the rectouterine pouch in a woman 14 weeks pregnant.
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Fragments od bacterial DNA presence in hemodialisis patients’ blood-preliminary report

Cardiovascular disease (CVD) accounts for most of morbidity and mortality in patients with end-stage renal disease treated by chronic hemodialysis. The idea that inflammation state present in uremia plays an important role in the development of atherosclerosis has enjoyed much attention. We have investigated therefore pos- sible presence of bacterial DNA in the blood of chronically hemodialyzed patients. There were retrospectively studies of 59 patients without any signs of active infection, who had been undergoing intermittent HD. In 54 among 59 investigated DNA blood samples from HD patients we were able to detect a DNA fragment about 790 bp in length, consistent with the presence of 16sRNA bacterial DNA. Bacterial DNA could not be detected in any of the samples from control subjects. We were not able to detect bacterial DNA in any of 9 investigated dialysate samples although in 4 blood samples of these patients bacterial DNA encoding ribosomal RNA was observed. Bacterial DNA is detectable in blood of HD patients. This might be one of the inflammatory stimuli.
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Dengue, for apparatus and systems

In daily clinical practice we are all familiar with the word „ dengue „ making us think of an acute febrile illness.In order to obtain an overview of the aforementioned, we dengue to various organ systems of human body.
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Dengue vs. Leptospirosis, diagnosis and treatment from the first contact

Dengue infection occurs, without doubt, at high incidence and prevalence rates in endemic tropical areas, including Mexico. Another big issue that physicians from the emergency room are facing, are infections that often simulate dengue symptoms, primarily through the bacterial infection caused by Leptospira, whose rate has increased in some regions. Unfortunately, there is no specific diagnosis done in this matter. Below there is a series of comparisons between the two infections listed. Both clinical and biochemical data has been pro- vided for this cause.
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Bionic Pancreas and Bionic Organs – how far we are from the success

The progress in the treatment of chronic diseases of civilization that occurred in recent years, led to a signi- ficant prolongation of median survival time of the developed countries societies. Organ transplantation has revolutionized medicine as it became possible to replace an irreversibly diseased organ. However, at the moment we can observe a significant shortage of organs for transplantation, which forces doctors to accept those coming from more and more expanding criteria donors. No doubt, the number of donors, at best, will certainly not grow. Tissue engineering and regenerative medicine methods are extremely promising, in par- ticular bioprinting of tissues and organs, which begun to develop at the beginning of the XXI century. Article highlights possible future direction of organ transplantation.
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MEDtube Science – Issue 3, September 2015

Dear Colleagues,

We are pleased to present another issue of MEDtube Science – an open access publication distributed online.
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Arterial supply of gastric fundus in human – final results

Background: General scheme of stomach arterial supply is well known and was repeatedly described but there are only few reports about gastric fundus arterial supply.

The aim of the study is to describe the anatomy of the gastric arterial fundic branches with special reference to their selected morphometric and morphologic features, determination of the relationship between certain gastric arterial fundic branches and the selected gastric ligaments and indication of the exact site of the arterial fundic branches perforation in relation to its quadrants (defined vascular areas).

Material and methods: The study was performed on 50 samples taken during post-mortem autopsy. In the whole material, a total 304 gastric arterial fundic branches were identified and measured. Statistical analysis was performed.

Conclusions: The splenic artery almost always participates in gastric fundus arterial supply and other arteries inconstantly participate in the process . There are three morphological types of arterial fundic branches. The branches occurring in the superior part of gastro-splenic ligament usually supply posteromedial quadrant. Sequence of quadrants in terms of number of arterial branches supplying them is as follows: the postero-lateral, postero-medial, antero-medial and antero-lateral. There were no differences in gastric fundus arterial supply between males and females
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Pain threshold – self- inflicted injuries with the intent to commit suicide

Every human being is a unique entity characterized by different pain thresholds. It may be assumed that the limits of pain actually exist.

In the court-appointed physician’s practice, there exist self-mutilation suicide cases which are distinguished by numerous and severe body injuries. People who commit suicide in this manner have different pain inflicted perception than others. Otherwise, it would be beyond their capacity to harm themselves and inflict such damage and pain on their body.

From the psychiatry perspective, self-mutilation is defined as intentional and deliberate injury infliction on one’s own body, a self-destructive behavior. This type of behavior may be of non-suicidal nature but often directly leading to death. Article shows a few cases, which were seen in the department of forensic medicine of Warsaw Medical University. This article showes that suicide cases with extensive self-harm done on body are interesting, not only from the standpoint of debate on self-injury inclination, but also from the standpoint of going beyond human physiological barriers associated with containing typical body’s response to pain stimuli. While the discussion drew attention to the possible potential mechanisms explaining this phenomenon, yet this topic requires further study.
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Transplantational microchimerism – an introduction to a tolerance induction or an organ donor recipient’s epiphenomenon?

Microchimerism is a presence of a small amount of cells, as well as genetic material that come from another organism. Scientists are trying to prove influence of transplantational microchimerism on different reactions that can be observed in a transplatology medicine. Conclusions are controversial and still there are no unambiguous premises regarding microchimerism. The immunological tolerance is a characteristic lack of the immunological system response to specific antigens. An achievement of full tolerance to transplanted organ can produce a possibility of discontinuation of immunosuppressive therapy and avoiding its side effects. Getting to know the real biological role of microchimerism may contribute to more effective monitoring of patients’ immunological status and immunosuppressive therapy dosage. However, it may turn out to be only an epiphenomenon connected with organ transplantation.

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Is Eating Seville Oranges Dangerous?

Background. Grapefruits are commonly recognized as a cause of drugs interactions through affecting the cytrochrome P450 (CYPs). Large and diverse family of CYPs are protein enzymes with monooxygenase activity involved in both, the activation and detoxification metabolism of xenbiotics. Because of their function, they have been widely researched in vitro and in vivo. There are reports that different exotic fruits have effect on CYP proteins. The aim of this paper is to review recent research articles in order to identify fruits and their juices interfering with the metabolism of drugs and thus endangering the treatment of chronic diseases.

Material and Methods. A systematic review of the literature from PubMed resource with access to MEDLINE was performed. Summaries were obtained from 15 articles published between 1997 and 2014 and closely related to the given keywords. Of these 15 articles, 4 (published between 2002-2012) were fulfilling the pre-determined criteria and were assessed in details.

Results and conclusion. Seville oranges and their juice can endanger the treatment of chronic diseases through inhibition of cytochrome P450 and drug interactions. The diet of transplanted organ recipients should be controlled and they should avoid not only grapefruit, but also Seville orange consumption. Read full text »