Effect of Left Ventricular Systolic Dysfunction on Renal Transplantation Outcomes- A Paired Kidney Analysis

Background: Reduced left ventricular ejection fraction (LVEF) is thought to be a rel-ative contraindication for kidney transplantation (KT). It is not clear how to manage congestive heart failure (CHF) due to left ventricular systolic dysfunction in patients with end-stage renal disease (ESRD). Material and Methods: A total of 21 kidney recipients transplanted between 2011 and 2013 who had LVEF <55% were ana-lysed in this retro- spective single-centre study. This group was compared with 21 patients with LVEF ≥ 55% who had received another kidney from the same de-ceased donor. The mean duration of follow-up was 32Ī10 months. Results: Con-cerning post – transplant characteristics there were no significant differences be-tween groups regarding rate of urinary tract infection after transplantation, level of serum creatinine at 12 months post KT, patient survival and subjective opinion of patient about their ability to physical effort at the end of follow up comparing to pre-transplant condition. In the group with reduced EF there were more incidences of delayed graft func- tion(28.8% vs 14.3%, p=0.29)and lower rate of graft survival( 85.7% vs 100%, p=0.23) but the differences did not reach statistical significance. Conclusion: Reduced EF should not exclude patients from consideration for KT, however greater caution is recommended.

Authors:

Michal Gniewkiewicz, Marta Serwanska-Swietek, Michal Wszola et al

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