The Correlation Between Living Donor’s Glomerular Filtration Rate and Early Kidney Allograft Function

Abstract: Glomerular filtration rate of living kidney donor candidate must be appropriate to provide him sufficient filtration after unilateral nephrectomy and to ensure satisfactory renal graft function to recipient as well. Predictors for immediate function of living donor kidney transplant have not been well defined yet in the literature. Meanwhile, immediate graft function is well-known as closely related with better long-term outcome of transplantation procedure. The aim of the study was to analyse the impact of donor’s pre-donation estimated glomerular filtration rate on initial function of living donor kidney allograft. Analysed set consisted of 129 living kidney donors. Comparative analysis was performed between IGF Group (including cases with immediate graft function defined as recipient’s serum creatinine concentration below 3 mg/dl in 5th postoperative day) and Non-IGF Group (consisted of all other cases). GFR was estimated before nephroureterectomy procedure with using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. There were 82 cases in the mean age of 44.8±10.54 years (55 were female) included to IGF Group and 47 cases in the mean age of 47.22±11.04 years (35 were female) included to Non-IGF Group. Mean GFR was estimated at 97.66±14.64 ml/min/1.73m2 (ranged, 63.07 – 123.40 ml/min/1.73 m2 ) in the IGF Group vs. 90.82±16.24 ml/min/1.73 m2 (ranged, 50.6 – 125.24 ml/min/1.73 m2 ) in Non-IGF Group. The finding was statistically significant (p=0.018). The optimum GFR cut-off point was calculated at 97.04 ml/min/1.73 m2 in analysed cohort. Higher donor’s glomerular filtration rate correlates with the incidence of immediate graft function in living donor kidney transplantation, thus also affects long-term outcome.

Authors:
Kwapisz Magdalena, Kieszek Rafal, Bieniasz Monika, Jedrzejko Kalina, Kwiatkowski Artur

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