PD-1 is a receptor which, through a variety of metabolic processes, leads to inactivation of T cells. In the therapy of the cancer, one of the promising new drugs is BMS-936 558, an antibody directed against PD-1 receptor. The effectiveness of the new therapy has been demonstrated in large randomized trials for renal cancer, non-small cell lung cancer and melanoma. Currently, the drug is in the second phase of clinical trials (treatment of renal cell carcinoma). The obtained results are very promising, however the effect of the antibody must be evaluated in the further studies.
Statins are one of the world’s most commonly prescribed drugs (1). They are used to lower cholesterol level by inhibiting hydroxy-methylglutaryl-coenzyme A reductase (HMG-CoAR), which is an essential enzyme for synthesis of endogenous cholesterol. Clinical benefits of statins therapy may be greater than changes in lipid profile. Read full text »
The use of laser in medicine has more than fifty years of history. Currently, laser radiation is used in the following specializations: surgery, dermatology, gynecology, aesthetic medicine and others Read full text »
Trigeminal neuralgia is disorder characterized by intense recurrent attacks of severe and lancinating pain in the trigeminal nerve distribution area. It frequently causes deep distress and lowers the quality of patients lives in general. The attacks can be triggered by everyday activities such as eating or smiling. Before the correct diagnosis made, it sometimes happens that patients are forced to undergo wrong treatments like complicated oral surgeries or teeth extractions, which leads to a profound sense of injustice and sometimes complete isolation. Read full text »