Parkinson’s disease (PD) is a disorder belonging to a large group of neurodegenerative diseases. One of the features of most of these disorders of the central nervous system (CNS) is the unknown pathogenesis. The same applies to PD. Recent studies show that abnormal polyamine biochemical changes in the CNS may cause neurotoxicity responsible for the development of PD. Read full text »

Sirtuins known as Sirt2 proteins are enzymes, NAD+-dependent deacetylases. Seven homologues of sirtuins (SIRT 1-7) were identified in mammals, which differ in location in cells, activity, function. They play an important role in metabolic processes, aging processes, growth and proliferation. Researchers have been working to find possibility of modulation of biological activity in treatment of metabolic diseases or age-related diseases. Read full text »

Scientific research on supercomputer simulations of cytochrome P450 has been published in the Biophysical Journal. The article describes a virtual presentation of the actual activity of the enzyme. Simulation was performed to better understand the detoxifying role of the cytochrome P450 and facilitate further studies. Read full text »

Alzheimer’s disease is a type of dementia that causes problems with memory, thinking and behavior. Symptoms usually develop slowly and get worse over time, becoming severe enough to interfere with daily tasks. A brain scan identifies biochemical changes in the brains of normal people, who might be at risk for Alzheimer’s Disease. Results of new study have been published in Neurology, the medical journal of the American Academy of Neurology. Read full text »