Nearly 2 years ago we reported the first study on the association between resveratrol and endometriosis, the disease involving most frequently pelvic pain and infertility (1). The preliminary tests (2) on mice showed that the organic antioxidant poliphenol might have application in therapy of endometriosis. This devious disease seems to escape every treatment option, so the prospect was more than promising. Today we see that resveratrol has come up to our expectations. A group of Brazilian scientists conducted an interesting clinical trial (3) investigating the impact of resveratrol added to conventional oral contraceptives on pain level. In addition the researchers examined the expression of aromatase (enzyme responsible for aromatization of androgens into estrogens) and cyclo-oxygenase-2 in the endometrial tissue. Both tests provide encouraging results. Read full text »

The comorbidity of endometriosis and migraine was first discovered in 1975, but until now has not been fully acknowledged. Although both diseases share some epidemiological and clinical features, the nature of their relationship remains unclear. Does endometriosis cause headaches? Or is it migraine that makes endometriosis more detectable? Why do they have so much in common? These issues are discussed in the population-based study performed by Taiwanian scientists, which proves that indeed „women with endometriosis are more likely to suffer from migraines” (1). Read full text »

Approximately 10% women are thought to be affected with endometriosis. An understanding of its pathogenesis seems to be rather poor, though the scale of the problem is large. Limited to conventional hormonal therapies and surgical intervention, women usually suffer from adverse effects that make the disease even more psychically and psychologically debilitating. Recent advances in the field of discovering endometriosis’ etiology lead to surprising findings. The underestimated potential of statins gives hope for their application in endometriosis treatment. New selective estrogen modulators might also come in handy. What is more, the greater insight into the role of stem cells in development of endometrial lesions may result in therapy targets that no one ever thought of. Read full text »

Latest study shows that resveratrol, red wine derived and known for its anti-inflammatory properties, reduces development and progression of endometriosis in mice model and decreases the invasiveness of endometrial tissue in vitro. Read full text »