The average age of onset of polyposis in FAP is 16 years. The average age of onset for colorectal cancer is 39 years. The average age of onset for polyps in AAPC is 36 years, and the average age of onset for cancer in AAPC is 54 years. These patients have fewer polyps (approximately 30 polyps) compared to patients with FAP. Most patients with FAP are asymptomatic until they develop cancer. As a result, diagnosing presymptomatic patients is essential. Of patients with FAP, 75-80% have a family history of polyps and/or colorectal cancer at age 40 years or younger.
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