The most significant complication is the development of adenocarcinoma in the esophagus. Recent data suggest that the risk of dysplasia is strongly associated with increasing age of the patient and the segment length of Barrett's esophagus. Although Barrett's esophagus is the only known precursor to esophageal adenocarcinoma, most patients with Barrett's esophagus do not develop cancer. Barrett's esophagus has a 2-25% risk of mild-severe dysplasia and a 2-5% risk of developing adenocarcinoma. 40-50% of those patients with Barrett's esophagus and severe dysplasia go on to develop esophageal adenocarcinoma within 5 years.
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