A 66 year-old male with chronic gastroesophageal reflux disease. Barrett's esophagus is a condition in which an abnormal columnar epithelium replaces the stratified squamous epithelium that normally lines the distal esophagus. It is the most severe histologic consequence of chronic gastroesophageal reflux and predisposes to the development of adenocarcinoma of the esophagus. Endoscopically obvious Barrett's esophagus can be seen in 3 to 12 percent of patients who have endoscopic examinations for symptoms of GERD.
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