Esophageal Varix - Bleeding (15 of 15)

The kidney is continuously generating free water in the
ascending limb of the loop of Hente by a mechanism
consisting in an active reabsorption of sodium chloride
without a concomitant reabsorption of water. The final
volume free water excretion, therefore, depends on the
amount of free water reabsorbed in the more distal
segments of the nephron, the convoluted distal tubule and
the collecting tubule. This process is mediated by
antidiuretic hormone (ADH) When ADH is completely
inhibited, for example following a water load of 20 mL/kg
of body weigh, the distal nephron is almost completely
impermeable to water, leading to the excretion of a high
urine volume (10 mL/min or more) with low urine
osmolality.